Melan® by Krulig is the best known and effective worldwide skin depigmentation system of skin blemishes. It has been created by Dr. Eduardo Krulig, Venezuelan Plastic and Reconstructive Surgeon of Polish origin result of several years of research. Amelan® by Krulig was the first system in which seven active principles were integrated with a single active depigmenting formula, (1990-1985) which was a novelty in the treatment of skin hyperpigmentation of melanic origin